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Olfactory deficits in aging and Alzheimer's-spotlight on inhibitory interneurons.
Front Neurosci
December 2024
Institute of Physiology, RG Neurophysiology and Optogenetics, Medical Faculty, Otto-von-Guericke-University, Magdeburg, Germany.
Cognitive function in healthy aging and neurodegenerative diseases like Alzheimer's disease (AD) correlates to olfactory performance. Aging and disease progression both show marked olfactory deficits in humans and rodents. As a clear understanding of what causes olfactory deficits is still missing, research on this topic is paramount to diagnostics and early intervention therapy.
View Article and Find Full Text PDFUS regulatory compliance for medical combination products: an overview.
Front Med Technol
December 2024
Advance Academic Programs, Krieger School of Arts and Sciences, Johns Hopkins University, Washington, DC, United States.
This article provides a high-level overview of US regulatory review and approval processes for the growing field of medical combination products (CPs; those merging drugs with devices and/or biological products). US law defines drugs, medical devices, and CPs in specific ways, and the components of a CP are still subject to their respective regulations while combined. The Food and Drug Administration's Office of Combination Products (OCP) oversees the review and classification of CPs, which is based on their primary mode of action.
View Article and Find Full Text PDFDysphagia in multiple sclerosis: pathophysiology, assessment, and management-an overview.
Front Neurol
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Unit of Neurology, IRCCS Neuromed, Pozzilli, Italy.
Dysphagia is a frequent and life-threatening complication of multiple sclerosis (MS). Swallowing disturbances may be present at all stages of MS, although their prevalence increases with age, with disease duration, and in progressive phenotypes. The pathophysiology of dysphagia in MS is likely due to a combination of factors, including the involvement of corticobulbar tracts, the cerebellum, and the brainstem.
View Article and Find Full Text PDFEditorial overview: Regaining architecture and cell cross-talk upon regeneration.
Curr Opin Genet Dev
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Institute of Molecular and Cell Biology (IMCB), and National University of Singapore (NUS), Singapore. Electronic address:
Botulinum Toxin and Migraine: Goals and Perspectives.
Toxins (Basel)
December 2024
Headache Center, Neurological Clinic, "L. Amaducci", AOUC Policlinico, Piazza G. Cesare, 11, 70124 Bari, Italy.
This Special Issue aims to provide an updated overview of the current state and future perspectives of botulinum toxin treatment for migraine [...
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