Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?

Annu Rev Physiol

Department of Neurology and the Columbia University Motor Neuron Center, Columbia University Medical Center, New York, NY, USA; email:

Published: February 2023

AI Article Synopsis

  • Internal body models are crucial for sensorimotor control, relying on proprioceptive feedback to update how we perceive our body's position.
  • The mechanisms for transforming this sensory input into a body awareness are still not fully understood, but new genetic tools are helping to explore which brain pathways are involved.
  • Additionally, advancements in bionic neural machine interfaces are providing valuable information about the significance of kinesthetic feedback and the brain's proprioceptive functions related to natural movements.

Article Abstract

The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory feedback, the underlying mechanism that transforms this sensory feedback into a dynamic body percept remains poorly understood. However, advances in the development of genetic tools for proprioceptive circuit elements, including the sensory receptors, are beginning to offer new and unprecedented leverage to dissect the central pathways responsible for proprioceptive encoding. Simultaneously, new data derived through emerging bionic neural machine-interface technologies reveal clues regarding the relative importance of kinesthetic sensory feedback and insights into the functional proprioceptive substrates that underlie natural motor behaviors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10810321PMC
http://dx.doi.org/10.1146/annurev-physiol-040122-081302DOI Listing

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