Purulent-inflammatory lesions of skin and soft tissues account for 30-35% of causes of admission to surgical hospitals. In outpatient system, this value reaches 35-60%. Moreover, suppuration of wounds after elective surgery occurs in 2-5% of cases. Adequately selected drugs for local wound therapy can achieve localization of purulent process and avoid spread of infection. This review summarizes data on development, experimental and clinical testing of wound dressings over the past 10 years, presents classification options and analyzes their advantages and disadvantages. The authors emphasize higher efficacy of hydrophilic coatings, and coatings based on chitosan, collagen, methylcellulose and its derivatives are preferred. It is advisable to introduce a component with antimicrobial, anesthetic and hemostatic activity stimulating tissue regeneration into the matrix of wound dressing. The priority is introduction of antiseptic substances causing fewer side effects compared to antibiotics. Further research and development of new wound dressings is a priority in surgery considering changing landscape and development of resistance of microorganisms.
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http://dx.doi.org/10.17116/hirurgia202211142 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, PR China; Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, PR China. Electronic address:
Tissue adhesives have attracted wide attention as alternatives to sutures. Further developments in adhesives with excellent adhesion and biocompatibility for wet tissue surfaces are still required. This study provides a new solution for the development of bioadhesives for use on tissue surfaces under wet conditions.
View Article and Find Full Text PDFBiomaterials
January 2025
Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. Electronic address:
The chronic inflammation and matrix metalloprotease (MMP)-induced tissue degradation significantly disrupt re-epithelization and delay the healing process of diabetic wounds. To address these issues, we produced nanofibrils from Antheraea pernyi (Ap) silk fibers via a facile and green treatment of swelling and shearing. The integrin receptors on the cytomembrane could specifically bind to the Ap nanofibrils (ApNFs) due to their inherent Arg-Gly-Asp (RGD) motifs, which activated platelets to accelerate coagulation and promoted fibroblast migration, adhesion and spreading.
View Article and Find Full Text PDFPLoS One
January 2025
CNPQ (Researcher PQ1D), Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Our objective was to assess the effect of Venous Leg Ulcer (VLU) healing on Quality of Life (QoL) in patients undergoing compression therapy. This non-randomized, quasi-experimental, and observational study involved patients with VLU. A convenience sample of individuals receiving services was followed for at least one year while undergoing compression therapy.
View Article and Find Full Text PDFNiger Med J
January 2025
Department of Medical Microbiology, Usman Danfodiyo University Teaching Hospital, Sokoto, Nigeria.
Background: Anthrax is a life-threatening zoonotic disease caused by Gram-positive, spore-forming bacterium . It manifests as a cutaneous, gastrointestinal, and respiratory disease. The cutaneous form ranges from a self-limiting lesion to severe edematous lesions with toxemic shock.
View Article and Find Full Text PDFANZ J Surg
January 2025
Department of Surgery, Eastern Health, Melbourne, Victoria, Australia.
Enteroatmospheric fistula is a severe complication associated with an open abdomen, and management of this can be challenging. This article describes a practical and accessible wound management option for enteroatmospheric fistula using a generic silicone bottle teat and vacuum-assisted closure dressing.
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