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Cytokine profiling in patients with polypoidal choroidal vasculopathy before and after intravitreal injection of ranibizumab. | LitMetric

AI Article Synopsis

  • This study investigates cytokine levels in the aqueous humor of patients with polypoidal choroidal vasculopathy (PCV) before and after treatment with ranibizumab.
  • 14 patients with PCV and 15 control patients underwent aqueous humor sampling during cataract surgery and intravitreal injection.
  • The results showed lower levels of certain inflammatory cytokines in PCV patients compared to controls, while VEGF-A levels were higher in PCV patients; IVR treatment significantly altered these levels, indicating a complex interplay of inflammatory and angiogenic factors in PCV.

Article Abstract

Objective: This study aims to investigate the cytokines profiling in the aqueous humor of patients with polypoidal choroidal vasculopathy (PCV) before and after intravitreal ranibizumab injection (IVR).

Methods: 14 patients clinically diagnosed with PCV and 15 cataract patients of similar age and gender (control group) were included. Throughout the cataract surgery and IVR, aqueous humor samples were collected from the PCV and control groups.

Results: The levels of macrophage inflammatory protein 1β (MIP-1β) and normal T cell expressed and secreted (RANTES) in PCV patients were significantly lower than control subjects (P=0.045 and P=0.004, respectively). The concentration of vascular endothelial growth factor-A (VEGF-A) was significantly higher than the control group (P=0.003). The level of MIP-1β was greatly increased in PCV patients compared to prior to IVR (P=0.001). After IVR, the level of VEGF-A in PCV patients were considerably lower compared to before IVR (P=0.001). There was no link between the expression of several cytokines (MCP-1, MIP-1, Eotaxin, G-CSF, IL-8, IL-6, IL-5, IP-10 and IFN-γ) in the aqueous humor of PCV patients before and after intravitreal ranibizumab injection (IVR). The association between IL-5 expression and central macular thickness (CMT) was discovered before IVR (P=0.02), however, the correlation between several cytokines (MCP-1, MIP-1, Eotaxin, G-CSF, IL-8, IL-6, IL-5, IP-10 and IFN-γ) was discovered in PCV patients after IVR.

Conclusion: Based on our findings, we discovered that the production of neovascularization in PCV patients is driven by both angiogenic and inflammatory factors, with a correlation seen between several cytokines.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641452PMC

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