AI Article Synopsis
- Sepsis is a severe condition caused by infections that leads to organ dysfunction, and there's a need for standardized biomarkers to improve patient care, especially in ICUs.
- The study aimed to establish a NAMPT-associated biomarker by analyzing gene expression profiles, identifying a 19-gene signature that predicts survival in sepsis patients.
- This newly identified 19-gene NAMPT signature effectively differentiates high-risk from low-risk sepsis and shows better prognostic capability compared to random gene sets, potentially enabling early interventions in treatment.
Article Abstract
Objective: Sepsis is a life-threatening condition of severe organ dysfunction induced by uncontrolled infection and dysregulated host response. However, standardized clinical biomarkers for sepsis are needed to improve patient care, especially in intensive care units (ICUs). Nicotinamide phosphoribosyltransferase (NAMPT) regulates the activity of nicotinamide adenine dinucleotide (NAD)-dependent enzymes and modulates multiple metabolic pathways. Elevated NAMPT gene expression is a risk factor in the pathogenesis and development of sepsis, which is strongly linked to patient morbidity and ICU mortality. At present, there is no identified NAMPT gene signature for prognosis of sepsis patients.
Methods: By analyzing gene expression profiles in peripheral blood mononuclear cells, this study was designed to establish a NAMPT-associated biomarker that effectively predicts survival in sepsis patients.
Results: We obtained 19 common genes by intersecting NAMPT-associated genes and sepsis survival-related genes, and this 19-gene signature is significantly enriched in metabolic pathways and NF-κB pathways related to sepsis development. Notably, this 19-gene NAMPT signature was able to discriminate high-risk sepsis from low-risk sepsis in both discovery and validation cohorts. Furthermore, we confirmed that this 19-gene NAMPT signature performed significantly better for sepsis prognosis than random gene sets with 19 genes.
Conclusions: We identified a novel NAMPT gene signature with effective prognostic power for sepsis. Further studies focusing on these biomarkers may also provide an early intervention system for sepsis treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641493 | PMC |
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