The interpretation of hepatocholangial laboratory test results is challenging. Possible liver biochemical tests include the evaluation of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, 5'-nucleotidase, lactate dehydrogenase, bilirubin, and albumin levels, as well as prothrombin time and international normalized ratio. When liver enzyme levels are elevated, R-values are generally used for diagnosis. A 62-year-old woman presented to our hospital with the chief complaint of abdominal pain and was consequently diagnosed with gallstone hepatitis based on her blood test results. Generally, gallstone hepatitis manifests as elevated liver enzyme levels showing a hepatocellular pattern, while common bile duct obstructions show a cholestatic pattern. Since gallstone hepatitis is indistinguishable from viral and ischemic hepatitis in the early stages of onset, it is vital to monitor changes in symptoms, biochemical tests, and imaging results over time to diagnose this disease.
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http://dx.doi.org/10.7759/cureus.30192 | DOI Listing |
Therap Adv Gastroenterol
January 2025
Department of Gastroenterology, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China.
Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), can affect the hepatobiliary system and pancreas, substantially impacting the life quality of patients.
Objectives: To evaluate the quality of evidence and comprehensively assess the validity of associations of IBD with hepatobiliary and pancreatic diseases.
Design: We performed an umbrella review of existing meta-analyses in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) recommendations.
Cureus
October 2024
Internal Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, USA.
Goldenhar syndrome, also known as oculo-auriculo-vertebral dysplasia or hemifacial microsomia, is a rare congenital anomaly involving the first and second branchial arches. In this case report, we present a distinctive instance of a 43-year-old male with Goldenhar syndrome who presented with nausea and recurrent bilious vomiting. Initial diagnostic imaging raised concerns about pancreatitis, leading to a comprehensive evaluation that revealed gallstone pancreatitis as the cause of his symptoms.
View Article and Find Full Text PDFRadiographics
December 2024
From the Departments of Radiology (R.P., J.R.T., L.S., A.K.) and Pathology (D.B.B.), Stanford University, 300 Pasteur Dr, Palo Alto, CA 94304.
Acute cholecystitis is an inflammatory condition of the gallbladder typically incited by mechanical obstruction. Accurate diagnosis of this common clinical condition is challenging due to variable imaging appearances as well as overlapping clinical manifestations with biliary colic, acute hepatitis, pancreatitis, and cholangiopathies. In acute cholecystitis, increased dilatation and high intraluminal pressures lead to gallbladder inflammation and may progress to gangrenous changes, focal wall necrosis, and subsequent perforation.
View Article and Find Full Text PDFLife Sci
December 2024
Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, China; Shenzhen Research Institute, The Hong Kong Polytechnic University, Hong Kong, China; Research Centre for Chinese Medicine Innovation (RCMI), The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:
Hepatic steatosis, characterized by excessive lipid accumulation in the liver, can be ameliorated by autophagy activation. Polygoni Cuspidati rhizome et Radix (PCRR), traditionally used to treat atherosclerosis, hepatitis, and gallstones, has recently demonstrated anti-steatotic effects in the liver. However, the active compounds and underlying mechanisms remain unclear.
View Article and Find Full Text PDFJ Gastrointest Surg
December 2024
Department of General Surgery, University of South Florida, Tampa, FL, United States. Electronic address:
Background: Hepatitis C (HCV) infection affects more than 2.2 million people in the United States and is associated with liver cirrhosis and gallstone formation. However, cholecystectomy outcomes of patients with and without HCV infection are not well studied.
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