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METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an mG-modified miR-760-dependent manner. | LitMetric
7-methylguanosine (mG) modification is recently found to conservatively exist in RNA internal position besides mRNA caps and mediates the various RNA metabolisms. As the core confirmed transmethylase of mG modification, METTL1 has been reported in certain human cancers. However, the role of internal mG at miRNAs and its core writer METTL1 in bladder cancer (BCa) remains to be elucidated. Here, we demonstrated that METTL1 was indispensable for BCa proliferation and metastasis in vitro and in vivo. By combining miRNA sequencing, mG methylated RNA immunoprecipitation (MeRIP) and RIP, we identified METTL1 promoted the processing of miR-760 in an mG-dependent manner. Transcription sequencing suggested that METTL1 indirectly degrades tumor suppressor ATF3 mRNA mediated by miR-760. Together, we concluded a regulatory axis composed of METTL1/mG/miR-760/ATF3 in regulating BCa progression and provided potential therapeutic targets for BCa.
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