Multiple studies have investigated the association of () gene polymorphisms and osteoarthritis (OA) risk, but failed to reach a consistent conclusion. Therefore, this study was designed to elucidate the association of polymorphisms and OA by a meta-analysis approach. Literature retrieval was carried out on PubMed, EMBASE, Web of Science, CNKI, and Wanfang databases. The strength of association was appraised by odds ratios (ORs) and 95% confidence intervals (95%CIs) in five genetic models. The data were merged by using RevMan 5.3 software. Ten studies with 4944 cases and 4651 controls were analyzed. Overall, no significant association was identified between polymorphism and OA. Subgroup analysis by ethnicity and OA site also suggested polymorphism was not associated with OA. For polymorphism, G-allele and GG-genotype carriers appeared to have an increased risk to OA (G vs. C, OR = 1.66, 95%CI 1.30-1.96, < 0.01; GG vs. CC, OR = 1.75, 95%CI 1.07-2.84, = 0.03; GG vs. GC + CC, OR = 1.82, 95%CI 1.42-2.34, < 0.01). Findings of this study indicate that the polymorphism is not correlated to OA susceptibility, regardless of ethnicity or OA site. However, polymorphism trends to be associated with susceptibility to OA.
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