In the semi-supervised skeleton-based action recognition task, obtaining more discriminative information from both labeled and unlabeled data is a challenging problem. As the current mainstream approach, contrastive learning can learn more representations of augmented data, which can be considered as the pretext task of action recognition. However, such a method still confronts three main limitations: 1) It usually learns global-granularity features that cannot well reflect the local motion information. 2) The positive/negative pairs are usually pre-defined, some of which are ambiguous. 3) It generally measures the distance between positive/negative pairs only within the same granularity, which neglects the contrasting between the cross-granularity positive and negative pairs. Toward these limitations, we propose a novel Multi-granularity Anchor-Contrastive representation Learning (dubbed as MAC-Learning) to learn multi-granularity representations by conducting inter- and intra-granularity contrastive pretext tasks on the learnable and structural-link skeletons among three types of granularities covering local, context, and global views. To avoid the disturbance of ambiguous pairs from noisy and outlier samples, we design a more reliable Multi-granularity Anchor-Contrastive Loss (dubbed as MAC-Loss) that measures the agreement/disagreement between high-confidence soft-positive/negative pairs based on the anchor graph instead of the hard-positive/negative pairs in the conventional contrastive loss. Extensive experiments on both NTU RGB+D and Northwestern-UCLA datasets show that the proposed MAC-Learning outperforms existing competitive methods in semi-supervised skeleton-based action recognition tasks.
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http://dx.doi.org/10.1109/TPAMI.2022.3222871 | DOI Listing |
Neuropsychologia
January 2025
Neuroscience Area, SISSA, Trieste, Italy; Dipartimento di Medicina dei Sistemi, Università di Roma-Tor Vergata, Roma, Italy.
Although gesture observation tasks are believed to invariably activate the action-observation network (AON), we investigated whether the activation of different cognitive mechanisms when processing identical stimuli with different explicit instructions modulates AON activations. Accordingly, 24 healthy right-handed individuals observed gestures and they processed both the actor's moved hand (hand laterality judgment task, HT) and the meaning of the actor's gesture (meaning task, MT). The main brain-level result was that the HT (vs MT) differentially activated the left and right precuneus, the left inferior parietal lobe, the left and right superior parietal lobe, the middle frontal gyri bilaterally and the left precentral gyrus.
View Article and Find Full Text PDFDokl Biochem Biophys
January 2025
Center for Strategic Planning and Management of Biomedical Health Risks, Federal Medical and Biological Agency, Moscow, Russia.
Unlabelled: The association of the pathogenesis of neurodegenerative diseases, depression, anxiety, and cognitive disorders with neurotrophin-3 deficiency determines the prospect of creating drugs with a similar mechanism of action. Since the use of full-length NT-3 is limited by unsatisfactory pharmacokinetic properties, the creation of low-molecular mimetics of neurotrophin-3 that are active when administered systemically is relevant. The Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies has created a dimeric dipeptide mimetic of the 4th loop of NT-3, hexamethylenediamide bis-(N-γ-oxybutyryl-L-glutamyl-L-asparagine) with the laboratory code GTS-302, which activates TrkC and TrkB receptors.
View Article and Find Full Text PDFNeuroSci
January 2025
Psychological Neuroscience Laboratory, Psychology Research Center, School of Psychology, University of Minho, Rua da Universidade, 4710-057 Braga, Portugal.
Human point-light displays consist of luminous dots representing human articulations, thus depicting actions without pictorial information. These stimuli are widely used in action recognition experiments. Because humans excel in decoding human motion, point-light displays (PLDs) are often masked with additional moving dots (noise masks), thereby challenging stimulus recognition.
View Article and Find Full Text PDFFront Microbiol
January 2025
Center for Foot-and-Mouth Disease Vaccine Research, Animal and Plant Quarantine Agency, Gimcheon-si, Republic of Korea.
Introduction: An effective vaccination policy must be implemented to prevent foot-and-mouth disease (FMD). However, the currently used vaccines for FMD have several limitations, including induction of humoral rather than cellular immune responses.
Methods: To overcome these shortcomings, we assessed the efficacy of levamisole, a small-molecule immunomodulator, as an adjuvant for the FMD vaccine.
EClinicalMedicine
February 2025
Human Stem Cell and Genome Engineering Center, University of California Los Angeles David Geffen School of Medicine, UCLA - CHS 36 - 125/133/143 650 Charles E. Young Dr. South, Los Angeles, CA, 90095, USA.
Background: Phosphodiesterase 5 (PDE5) inhibitors, owing to their mechanism of action, have been gaining recognition as a potential case of drug repurposing and combination therapy for diabetes treatment. We aimed to examine the effect of long and short half-life PDE5 inhibitors have on Haemoglobin A1c (HbA1c) levels.
Methods: A systematic review and meta-analysis was conducted of randomised controlled trials (RCTs) in people with elevated HbA1c (>6%) to assess mean difference in HbA1c levels from baseline versus controls after any PDE5 inhibitor intervention of ≥4 weeks, excluding multiple interventions.
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