AI Article Synopsis
- The study aims to compare different types of embolic protection devices (EPDs) used during carotid artery stenting (CAS) to see their effects on complications and ischemic lesions.
- A systematic review was conducted, analyzing 45 studies with 7600 participants, which found that Distal Filter (DF) and Distal Balloon (DB) strategies were linked to more new ischemic lesions compared to the Proximal Balloon (PB) strategy.
- Although PB was found to be more effective in reducing distal embolization, there were no significant differences in rates of periprocedural strokes or transient ischemic attacks (TIAs) among the EPDs.
Article Abstract
Objectives: Carotid artery stenting (CAS) is an alternative treatment option for patients at high risk for carotid endarterectomy (CEA) but has been correlated with increased risk for distal embolization and periprocedural stroke despite the use of adjunctive embolic protection devices (EPD). This study compared four types of EPDs and their intra and periprocedural related complications.
Methods: A systematic review of the literature was conducted in PubMed/Medline to identify studies that investigated the outcomes of CAS with adjuvant use of EPDs, including Proximal Balloon (PB), Distal Filter (DF), and Distal Balloon (DB) strategy. Continuous flow reversal performed via transcarotid approach by a commercially available device as an embolic protection strategy was intentionally excluded based on its distinct procedural characteristics and lack of availability outside of the United States. This network meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines.
Results: Overall, 45 studies, consisting of 7600 participants satisfied the predetermined search criteria and were included in this network meta-analysis. Overall, 13 studies provided data regarding the number of patients with new ischemic lesions detected in the DW-MRI. DF (OR: 3.15; 95% CI: 1.54-6.44; = 0.002) and DB (OR: 2.28; 95% CI: 1.58-3.29; < 0.001) were associated with higher odds of new ischemic lesions compared to PB on DW-MRI imaging. No statistical difference was identified between DB versus DF groups (OR: 1.48; 95% CI: 0.73-2.59; = 0.317). 36 and 27 studies reported on periprocedural stroke and transient ischemic attack (TIA) rates, respectively, showing similar odds of neurologic adverse events between all three groups.
Conclusions: PB deployment during CAS is superior to DF and DB in preventing distal embolization phenomena. However, no statistically significant difference in TIA and stroke rate was found among any of the analyzed EPD groups. Further research is warranted to investigate the association of embolic phenomena on imaging after CAS with clinically significant neurologic deficits.
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| http://dx.doi.org/10.1177/17085381221140616 | DOI Listing |
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