AI Article Synopsis

  • - The complete genome of *Escherichia coli* strain BR1220 contains a triple tandem IS composite transposon that carries a gene associated with quinolone resistance.
  • - This resistance gene is located on a 100-kb multidrug resistance plasmid, which has approximately 1.6 copies per chromosome (CPC).
  • - Additionally, there is a 2.6-kb Col(pHAD28) plasmid present, which shows a similar genetic region with about 27.8 CPC.

Article Abstract

The fully assembled genome of Escherichia coli strain BR1220 shows a triple tandemly arrayed IS composite transposon carrying a quinolone resistance gene in a 100-kb multidrug resistance plasmid (1.6 copies per chromosome [CPC]) and a 2.6-kb Col(pHAD28) plasmid (27.8 CPC) with a nearly identical gene region.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753673PMC
http://dx.doi.org/10.1128/mra.00661-22DOI Listing

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Article Synopsis
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  • - Their high variability is the result of different evolutionary paths from transposon-related ancestors, leading to significant differences in size, structure, and function among various Cas12 variants.
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