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Report from the World Health Organization's immunization and vaccines-related implementation research advisory committee (IVIR-AC) meeting, virtual gathering, 10-13 September 2024.
Vaccine
January 2025
Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
The Immunization and Vaccines-related Implementation Research Advisory Committee (IVIR-AC) is the primary advisory body of the World Health Organization conducting independent reviews of immunization-related implementation research, with a primary focus on transmission and economic modeling analyses that estimate the value and impact of vaccines. From 10 to 13th September 2024, IVIR-AC convened virtually for its second of two semi-annual meetings to provide feedback and recommendations across six sessions including: pneumococcal vaccination strategies that rely on indirect protection; vaccine impact modeling for chikungunya; The Lancet Commission on strengthening the use of epidemiological modeling of emerging and pandemic infectious diseases; methods for immunization coverage estimation; setting immunization research priorities in the South-East Asian Region; and modeling evidence related to typhoid conjugate vaccine schedules. This report summarizes the sessions, proceedings, and recommendations from that meeting.
View Article and Find Full Text PDFRadiation target nomenclature for lymphoma trials: consensus recommendations from the National Clinical Trials Network groups.
Lancet Haematol
December 2024
Department of Radiation Oncology, Mayo Clinic, Jacksonville, FL, USA; NRG Oncology, Philadelphia, PA, USA; Children's Oncology Group, Seattle, WA, USA. Electronic address:
Contemporary lymphoma radiation target volumes that rely on post-systemic therapy imaging do not have standardised nomenclature. A forum of radiation oncology lymphoma leaders from the National Clinical Trials Network groups (NRG Oncology, Children's Oncology Group, SWOG Cancer Research Network, Alliance for Clinical Trials in Oncology, Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group, and the Canadian Cancer Trials Group) was convened and established standardised nomenclature for these volumes in the autumn of 2024. Involved-site radiotherapy includes the full cranial-caudal extent of prechemotherapy disease and takes into account axial anatomical changes only.
View Article and Find Full Text PDFArticle Synopsis
- Quality of life (QoL) is crucial for monitoring therapies in Parkinson's disease patients (PwPD) and their caregivers, as both can experience a decline in QoL due to the disease’s varied symptoms and its psychosocial impact.
- A longitudinal study will track 1,000 PwPD and their caregivers over 20 years, assessing QoL through clinical data, self-reports, biospecimens, and MRI scans to better understand the factors influencing QoL.
- The findings aim to enhance diagnostics, prognostics, and therapy adjustments, with results slated for publication in peer-reviewed journals to ensure broad dissemination and impact.
Phase I and Randomized Phase II Study of Ruxolitinib With Frontline Neoadjuvant Therapy in Advanced Ovarian Cancer: An NRG Oncology Group Study.
J Clin Oncol
July 2024
Department of Medical Oncology, Kaiser-Permanente Northern California, San Francisco, CA.
Purpose: The interleukin-6/Janus kinase (JAK)/signal transducers and activators of transcription 3 axis is a reported driver of chemotherapy resistance. We hypothesized that adding the JAK1/2 inhibitor ruxolitinib to standard chemotherapy would be tolerable and improve progression-free survival (PFS) in patients with ovarian cancer in the upfront setting.
Materials And Methods: Patients with ovarian/fallopian tube/primary peritoneal carcinoma recommended for neoadjuvant chemotherapy were eligible.
Hub and Spokes-Implementation of Basic Palliative Care into University Hospital Practice-A Pilot Study.
J Palliat Med
July 2024
Institute of Emergency Medicine, University Hospital Zurich, Zurich, Switzerland.
The aim is to implement knowledge of basic palliative care in selected departments by the Hub and Spokes model. Implementation of basic palliative care was designed as a stepwise training model by skills lectures over a time period of 2 years. In each of the six selected oncological and nononcological departments, one physician and two nurses were trained in semi-annual half-day meetings as expert representatives within their departments.
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