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Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread.
PLoS Pathog
January 2025
Department of Translational Physiology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Gap junctions (GJs) play a pivotal role in intercellular communication between eukaryotic cells, including transfer of biomolecules that contribute to the innate and adaptive immune response. However, if and how viruses affect gap junction intercellular communication (GJIC) remains largely unexplored. Here, we describe how the alphaherpesvirus pseudorabies virus (PRV) triggers ERK1/2-mediated phosphorylation of the main gap junction component connexin 43 (Cx43) and closure of GJIC, which depends on the viral protein pUL46.
View Article and Find Full Text PDFPromotion of Cardiovascular Health in Africa: The Alliance for Medical Research in Africa (AMedRA) Expert Panel.
JACC Adv
December 2024
Alliance for Medical Research in Africa, Dakar, Senegal.
This proposed scientific statement is focused on providing new insights regarding challenges and opportunities for cardiovascular health (CVH) promotion in Africa. The statement includes an overview of the current state of CVH in Africa, with a particular interest in the cardiometabolic risk factors and their evaluation through metrics. The statement also explains the main principles of primordial prevention, its relevance in reducing noncommunicable disease and the different strategies that have been effective worldwide.
View Article and Find Full Text PDFDemographic and lifestyle characteristics impact lifetime prevalence of owner-reported intervertebral disc disease: 43,517 companion dogs in the United States.
J Am Vet Med Assoc
January 2025
2Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Objective: Intervertebral disc disease (IVDD) is a debilitating spinal condition that has been well studied among Dachshunds. However, little is known about IVDD prevalence across other dog breeds and associated lifestyle risk factors. The purpose of this study was to identify lifetime prevalence, demographic, and lifestyle factors associated with IVDD among a large population of companion dogs in the US.
View Article and Find Full Text PDFEnabling tumor-specific drug delivery by targeting the Warburg effect of cancer.
Cell Rep Med
January 2025
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address:
Metabolic reprogramming of tumor cells is an emerging hallmark of cancer. Among all the changes in cancer metabolism, increased glucose uptake and the accumulation of lactate under normoxic conditions (the "Warburg effect") is a common feature of cancer cells. In this study, we develop a lactate-responsive drug delivery platform by targeting the Warburg effect.
View Article and Find Full Text PDFComplex tissue regeneration in reveals a phylogenetic signal for enhanced regenerative ability in deomyine rodents.
Proc Natl Acad Sci U S A
January 2025
Department of Biology, University of Kentucky, Lexington, KY 40508.
Identifying why complex tissue regeneration is present or absent in specific vertebrate lineages has remained elusive. One also wonders whether the isolated examples where regeneration is observed represent cases of convergent evolution or are instead the product of phylogenetic inertia from a common ancestral program. Testing alternative hypotheses to identify genetic regulation, cell states, and tissue physiology that explain how regenerative healing emerges in some species requires sampling multiple species among which there is variation in regenerative ability across a phylogenetic framework.
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