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MR Imaging Features Predictive of Pathologic Complete Response and Survival Outcomes for Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.
Magn Reson Med Sci
March 2025
Department of Radiology, Izmir City Hospital, Izmir, Turkey.
Purpose: This study aims to evaluate the predictive value of MRI features for pathologic complete response (pCR) and survival outcomes in patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NAC).
Methods: A retrospective analysis was conducted on 168 BC patients treated with NAC between 2018 and 2022. Pre-NAC breast MRI scans were evaluated for enhancement patterns, time-intensity curve (TIC), peritumoral edema, and background enhancement.
Burden of diabetic macular oedema and its associated factors among adult patients with diabetes attending comprehensive specialised hospitals in Northwest Ethiopia, 2023: a multicentre cross-sectional study.
BMJ Open
March 2025
Department of Optometry, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia.
Objective: This study aimed to assess the prevalence of diabetic macular oedema and its associated factors among adult patients with diabetes attending comprehensive specialised hospitals in Northwest Ethiopia in 2023.
Design: An institution-based, cross-sectional study.
Setting: The study was conducted at the University of Gondar, Felege Hiwot and Debre Markos comprehensive specialised hospitals in Northwest Ethiopia from 8 May to 15 June 2023.
Structural characterizations and bioactivities of fucoidans from Dyctyopteris membranaceae and Padina pavonica with in silico investigations.
Int J Biol Macromol
March 2025
Laboratory of Pharmaceutical, Chemical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, Université de Monastir, Monastir, Tunisia.
Fucoidans, a complex water-soluble sulfated polysaccharide is regarded as a valuable source of new drug development. The aim of this study was to characterize the chemical properties of fucoidans isolated from two brown algae Dyctyopteris membranaceae and Padina pavonica and to evaluate their anti-inflammatory, gastroprotective, antioxidant and immunomodulatory activities. The characterization of fucoidans was investigated with colorimetric techniques and Fourier transform infrared spectroscopy.
View Article and Find Full Text PDFMetabolomic and molecular analysis reveals multiple pathways of TBBPA-induced developmental toxicity in zebrafish embryos.
Toxicol Appl Pharmacol
March 2025
Center of Molecular Metabolism, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address:
Tetrabromobisphenol A (TBBPA), a commonly utilized flame retardant, presents potential risks to both environmental and human health, with particular concern regarding its impact on embryonic development.This study employed zebrafish embryos as a model organism to investigate the comprehensive toxicological effects of TBBPA exposure, integrating metabolomics analysis with molecular and biochemical approaches. Embryos exposed to TBBPA concentrations ranging from 0.
View Article and Find Full Text PDFCorrelation of point-wise retinal sensitivity with localized features of diabetic macular edema using deep learning.
Can J Ophthalmol
March 2025
Department of Ophthalmology, Medical University of Vienna, Austria. Electronic address:
Purpose: To evaluate the association between localized features of diabetic macular edema (DME) and point-wise retinal sensitivity (RS) assessed with microperimetry (MP) using deep learning (DL)-based automated quantification on optical coherence tomography (OCT) scans.
Design: Cross-sectional study.
Participants: Twenty eyes of 20 subjects with clinically significant DME were included in this study.
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