AI Article Synopsis
- Anti-thyroid antibodies (ATA) are linked to infertility in 1 out of 9 women of childbearing age, potentially due to differences in calcium signaling in B cells.
- A study compared B lymphocyte responses to stimulation in women with Hashimoto's thyroiditis and infertility, finding those with ATA positivity had higher calcium levels and responses than healthy controls.
- Levothyroxine treatment reduced certain B cell markers and overall calcium levels, suggesting that calcium signaling may play a role in thyroid-related autoimmune conditions and infertility.
Article Abstract
Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca flux response of B lymphocyte subsets to BCR stimulation in Hashimoto's thyroiditis and related infertility. We collected peripheral blood samples from ATA+, infertile, euthyroid patients (HIE), hypothyroid, ATA+ patients before (H1) and after levothyroxine treatment (H2), and age-matched healthy controls (HC). All B cell subsets of ATA+, infertile, euthyroid patients showed elevated basal Ca level and hyper-responsivity to BCR ligation compared to the other groups, which could reflect altered systemic immune function. The Ca flux of hypothyroid patients was similar to healthy controls. The levothyroxine-treated patients had decreased prevalence of CD25 B cells and lower basal Ca level compared to pre-treatment. Our results support the role of altered Ca flux of B cells in the early phase of thyroid autoimmunity and infertility.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9641243 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.1039166 | DOI Listing |
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