AI Article Synopsis
- Dehydroepiandrosterone-sulfate (DHEAS) is a key androgen linked to various biological functions, and its relationship with cognitive decline is uncertain, especially in nonhuman primates like chimpanzees.
- A study assessed DHEAS and cortisol levels in 107 adult chimpanzees, with a closer look at 21 individuals to explore cognitive functions and their associations with hormonal levels while considering factors like age and sex.
- Results indicated that DHEAS levels decrease with age, and while the DHEAS/cortisol ratio was positively linked to cognitive function, it emerged as a better predictor of spatial cognition than DHEAS alone.
Article Abstract
Background: Dehydroepiandrosterone-sulfate is the most abundant circulating androgen in humans and other catarrhines. It is involved in several biological functions, such as testosterone production, glucocorticoid antagonist actions, neurogenesis and neuroplasticty. Although the role of dehydroepiandrosterone-sulfate (DHEAS) in cognition remains elusive, the DHEAS/cortisol ratio has been positively associated with a slower cognitive age-decline and improved mood in humans. Whether this relationship is found in nonhuman primates remains unknown.
Methods: We measured DHEAS and cortisol levels in serum of 107 adult chimpanzees to investigate the relationship between DHEAS levels and age. A subset of 21 chimpanzees was used to test the potential associations between DHEAS, cortisol, and DHEAS/cortisol ratio in cognitive function, taking into account age, sex, and their interactions. We tested for cognitive function using the primate cognitive test battery (PCTB) and principal component analyses to categorize cognition into three components: tasks, tasks, and tasks.
Results: DHEAS levels, but not the DHEAS/cortisol ratio, declined with age in chimpanzees. Our analyses for tasks revealed a significant, positive correlation with the DHEAS/cortisol ratio. had a negative relationship with age. Our data show that the DHEAS/cortisol ratio, but not DHEAS individually, is a promising predictor of spatial cognition in chimpanzees.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653054 | PMC |
| http://dx.doi.org/10.7717/peerj.14323 | DOI Listing |
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Article Synopsis
- Dehydroepiandrosterone-sulfate (DHEAS) is a key androgen linked to various biological functions, and its relationship with cognitive decline is uncertain, especially in nonhuman primates like chimpanzees.
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