Background: There is no established treatment for primary pulmonary lymphoepithelioma-like carcinoma (LELC) until now.

Case Summary: In this study, the patient responded well to sintilimab combined with paclitaxel and carboplatin, showing no obvious side effects. Meantime, the values of carbohydrate antigen 15-3 (CA15-3) and carbohydrate antigen 72-4 (CA72-4) gradually returned to normal.

Conclusion: Immunotherapy combined with chemotherapy in advanced-stage LELC may be more effective than immunotherapy or chemotherapy alone. CA15-3 and CA72-4 are biomarkers for evaluating therapeutic effects for LELC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649564PMC
http://dx.doi.org/10.12998/wjcc.v10.i31.11617DOI Listing

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