AI Article Synopsis
- Aging involves multiple processes, with senescence and chronic inflammation playing significant roles in its progression.
- Natural killer (NK) cells are crucial for eliminating senescent cells and reducing the negative effects of an aging immune system.
- Research using activated NK cells from patients showed a decrease in senescent cells and related inflammatory responses, highlighting their potential in addressing age-related immune decline.
Article Abstract
Aging is a multifactorial process involving many steps including senescence. The immune system plays a critical role in aging where chronic inflammation and senescence has been shown to be detrimental. Natural killer (NK) cells are the predominant innate lymphocyte subset that mediate various responses to include surveillance and elimination of senescent cells. Here, we use autologous propagated and activated NK (aNK) cells from 5 patients to demonstrate that aNK cells decrease senescent cells and immunosenescence in humans based on markers p16 and β-galactosidase. In addition, inflammatory cytokine panel data suggest a role for removal of immunosenescence to reduce the aging-related inflammatory response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661662 | PMC |
| http://dx.doi.org/10.1016/j.bbrep.2022.101380 | DOI Listing |
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