AI Article Synopsis
- The study aimed to evaluate how different types of general anesthesia (intravenous versus inhalation) affect serum HBV-DNA levels in patients with hepatitis B undergoing surgery.
- Blood samples were taken from 40 HBV-infected patients at various times around the surgery to measure HBV-DNA levels and immune cell ratios.
- Both anesthesia methods led to a significant decrease in HBV-DNA levels within 48 hours, with no notable differences in effectiveness between the two anesthesia types.
Article Abstract
Objective: To investigate the effects of different general anesthesia methods on the changes of serum hepatitis B virus deoxyribonucleic acid (HBV-DNA) levels in the hepatitis B virus (HBV) infected patients.
Methods: This pilot prospective observational study was carried out from March 2021 to January 2022. Forty patients infected by HBV, who underwent non-hepatobiliary minimally invasive surgery, were allocated into an intravenous anesthesia group maintained with propofol (Group P, n = 20) and an inhalation anesthesia group maintained with sevoflurane (Group S, n = 20) by a random envelope method. Patient's blood was drawn before operation (T), at 24 hours (T) and 48 hours (T) after operation to detect the serum HBV-DNA levels and analyze the subset levels of T, B lymphocytes and NK cells (TBNK) in two groups. The serum HBV-DNA level was used as the major outcome, and it was analyzed by repeated-measures analysis of variance after natural logarithm transformation.
Results: In Group P and Group S, compared with the baseline, the serum HBV-DNA levels decreased significantly at T and T, <0.05. The total ratio of CD4T cells and the ratio of CD4T to CD8T cells (CD4/CD8) were lower at T, <0.05, and the total ratio of B cells was significantly increased at T, <0.05. Compared with the values at T, the total ratio of CD4 T cells, CD4/CD8 T cells, and the total ratio of B cells were significantly increased at T in both groups, <0.05. However, there were no statistical differences between Group P and Group S.
Conclusion: The levels of serum HBV-DNA decreased within 48 hours after general anesthesia. There were no significant differences between the effects of intravenous and inhalation anesthesia on the serum HBV-DNA levels.
Trial Registration: This study has been prospectively registered in the Clinical Trials Registry (NCT02038088, 1/28/2015).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664914 | PMC |
| http://dx.doi.org/10.2147/IDR.S379350 | DOI Listing |
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