Redox-active N-(fluoromethoxy)benzotriazoles were made accessible from fluoroacetic acid and hydroxybenzotriazoles via electrodecarboxylative coupling. After alkylation, they become effective monofluoromethoxylation reagents, enabling the photocatalytic C-H functionalization of arenes. Thus, irradiation of 1-(OCH F)-3-Me-6-(CF )benzotriazolium triflate with blue LED light in the presence of [Ru(bpy) (PF ) ] promotes the synthesis of diversely functionalized aryl monofluoromethyl ethers. This method allows the late-stage functionalization of biologically relevant structures without relying on ecologically problematic halofluorocarbons.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107189 | PMC |
| http://dx.doi.org/10.1002/anie.202215920 | DOI Listing |
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