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Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice. | LitMetric

AI Article Synopsis

  • Rodents use vomeronasal receptors, influenced by dynamic Vr and Fpr gene superfamilies, to detect pheromones, with many V1r pseudogenes found in mammal genomes.
  • We found that V1r pseudogenes show higher expression when part of a functional gene cluster rather than when isolated.
  • Our research indicated that the clustered organization of functional vomeronasal genes is preserved due to transcription-stabilizing elements linked to the clusters, rather than to individual genes.

Article Abstract

Rodents perceive pheromones via vomeronasal receptors encoded by highly evolutionarily dynamic Vr and Fpr gene superfamilies. We report here that high numbers of V1r pseudogenes are scattered in mammalian genomes, contrasting with the clustered organization of functional V1r and Fpr genes. We also found that V1r pseudogenes are more likely to be expressed when located in a functional V1r gene cluster than when isolated. To explore the potential regulatory role played by the association of functional vomeronasal receptor genes with their clusters, we dissociated the mouse from its native cluster via transgenesis. Singular and specific transgenic transcription was observed in young vomeronasal neurons but was only transient. Our study of natural and artificial dispersed gene duplications uncovers the existence of transcription-stabilizing elements not coupled to vomeronasal gene units but rather associated with vomeronasal gene clusters and thus explains the evolutionary conserved clustered organization of functional vomeronasal genes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668312PMC
http://dx.doi.org/10.1126/sciadv.abn7450DOI Listing

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