In a pilot study (ClinicalTrials.gov NCT02646085), seven patients with treated multiple myeloma and negative FDG PET/CT underwent amino acid imaging with C-methionine PET/CT. In five participants, C-methionine PET/CT showed focal uptake corresponding with lytic lesions; two to 18 lesions were found (SUV, 2.8-6.4). Findings indicated a potential role for C-methionine PET/CT in detecting residual disease after negative FDG PET/CT, thereby guiding further treatment.
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Results of F-choline and C-methionine positron emission tomography/computed tomography for the preoperative localization of hyperfunctional parathyroid glands in primary hyperparathyroidism.
Surgery
January 2025
Department of Endocrine Surgery, Marienhaus Klinikum Mainz, Germany.
Background: Preoperative localization of hyperfunctioning parathyroid glands in primary hyperparathyroidism is essential for successful parathyroid surgery, particularly in patients with previous negative imaging or reoperations.
Methods: A multicenter registry study was performed in 776 patients with primary hyperparathyroidism from 53 hospitals in Germany and Austria who underwent parathyroid surgery after preoperative F-choline or C-methionine positron emission tomography/computed tomography (PET/CT).
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[Magnetic resonance imaging and PET/CT with 11C-methionine for primary central nervous system vasculitis].
Zh Vopr Neirokhir Im N N Burdenko
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Polenov Neurosurgical Institute, St-Petersburg, Russia.
Unlabelled: Primary central nervous system vasculitis is still a challenge due to rarity of disease, unspecific clinical and neurological presentation, as well as low specificity of MRI and laboratory tests.
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Imaging Recommendations for Diagnosis and Management of Primary Parathyroid Pathologies: A Comprehensive Review.
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Apollo Hospitals, Navi Mumbai 400614, Maharashtra, India.
Parathyroid pathologies are suspected based on the biochemical alterations and clinical manifestations, and the predominant roles of imaging in primary hyperparathyroidism are localisation of tumour within parathyroid glands, surgical planning, and to look for any ectopic parathyroid tissue in the setting of recurrent disease. This article provides a comprehensive review of embryology and anatomical variations of parathyroid glands and their clinical relevance, surgical anatomy of parathyroid glands, differentiation between multiglandular parathyroid disease, solitary adenoma, atypical parathyroid tumour, and parathyroid carcinoma. The roles, advantages and limitations of ultrasound, four-dimensional computed tomography (4DCT), radiolabelled technetium-99 (Tc) sestamibi or dual tracer Tc pertechnetate and Tc-sestamibi with or without single photon emission computed tomography (SPECT) or SPECT/CT, dynamic enhanced magnetic resonance imaging (4DMRI), and fluoro-choline positron emission tomography (F-FCH PET) or [C] Methionine (C -MET) PET in the management of parathyroid lesions have been extensively discussed in this article.
View Article and Find Full Text PDF[Differential diagnosis of epileptogenic substrates of unknown etiology using a modification of the routine MRI protocol].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2024
Pirogov Russian National Research Medical University, Moscow, Russia.
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