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Impact of Clinical Characteristics and Treatment on Cholangiocarcinoma Prognosis in Southern Thailand.
Cancer Med
December 2024
Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Article Synopsis
- Cholangiocarcinoma (CCA) patients in Southern Thailand exhibit late-stage diagnoses, with 59.4% diagnosed at TMN stage IV, and the overall median survival is only 5-6 months.
- The study reviewed 223 CCA patients between 2018 and 2021, identifying that intrahepatic CCA (iCCA) was the most common subtype (49.3%), and only 15.1% of patients were considered resectable.
- Key factors affecting survival included TMN stage, with a higher risk of mortality linked to late-stage diagnosis, while systemic chemotherapy and palliative biliary drainage improved outcomes for unresectable patients.
A Feasibility Study on 3-D Imaging of Intrahepatic Bile Ducts in Patients with Biliary Atresia Using Airy Beam Excited Two-Photon Microscopy.
Appl Biochem Biotechnol
December 2024
Department of General Surgery, Tianjin Children's Hospital, Beichen District, Longyan Road 238, Tianjin, 300134, China.
Article Synopsis
- This study aimed to use a two-photon microscope excitation Airy beam to create detailed 3D images of intrahepatic bile ducts in mice with bile duct ligation (BDL) and human patients with biliary atresia (BA).
- Ten BDL mice showed symptoms like jaundice and weight loss, with liver tissues sampled after 10 days, while 16 BA patients underwent either liver transplantation or Kasai portoenterostomy (KPE).
- The imaging revealed significant bile duct widening and hyperplasia in BDL mice and disorganized bile ducts in BA patients, particularly those who had liver transplants.
[Squamous cell carcinoma of the gallbladder with direct invasion to adjacent organs:a case report].
Nihon Shokakibyo Gakkai Zasshi
December 2024
Department of Surgery, Kitakyushu General Hospital.
Article Synopsis
- A 73-year-old woman experienced severe abdominal pain and was diagnosed with a malignant tumor in her gallbladder that had spread to nearby organs.
- She underwent an extensive surgery to remove the tumor and surrounding affected tissues, which revealed stage IVA squamous cell carcinoma.
- Despite initial treatment success, she suffered a recurrence of cancer and complications that led to her hospitalization; ultimately, she passed away 9 months after the surgery.
Chemoradiation of locally advanced biliary cancer: A PRISMA-compliant systematic review.
Cancer Med
December 2024
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - Bologna University, Bologna, Italy.
Introduction: Biliary tract cancers (BTC) are rare and aggressive neoplasms. The current management of locally advanced or unresectable BTC is primarily based on chemotherapy (CHT) alone, linked to a median overall survival (OS) of approximately 12 months. However, international guidelines still consider concurrent chemoradiation (CRT) as an alternative treatment option.
View Article and Find Full Text PDFCorrelation between liver volume drainage and clinical success after endoscopic biliary drainage of hilar malignant obstruction.
Clinics (Sao Paulo)
December 2024
Division of Endoscopy, Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil; Department of Gastroenterology of Universidade de São Paulo, São Paulo, SP, Brazil.
Background And Aim: Malignant hilar obstruction usually presents in advanced-stage disease with a poor prognosis. Effective biliary drainage is essential for the beginning of palliative chemotherapy. There is a debate on the amount of liver parenchyma that should be drained to achieve clinical success.
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