Hamman's Syndrome Accompanied by Diabetic Ketoacidosis; a Case Report.

Arch Acad Emerg Med

Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Published: August 2022

Hamman's syndrome is an uncommon clinical entity characterized by an idiopathic spontaneous pneumomediastinum as a result of a sudden increase in intra-alveolar pressure. It can be triggered by repeated vomiting or Kussmaul breathing associated with diabetic ketoacidosis (DKA). Careful attention to this particular condition is needed to avoid under-diagnosis and to provide optimal management. Herein, we report a case of an 18-year-old man complaining of chest discomfort and progressive weight loss, ultimately diagnosed with Hamman's syndrome secondary to DKA. The patient's symptoms disappeared after intravenous fluid and insulin administration, while his pneumomediastinum resolved following conservative treatment. Our report highlights the importance of recognition of the links between pneumomediastinum as a cause of chest pain in patients with DKA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637257PMC
http://dx.doi.org/10.22037/aaem.v10i1.1709DOI Listing

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Hamman syndrome, or spontaneous pneumomediastinum, is a rare condition characterized by the presence of free air in the mediastinum, often triggered by increased intrathoracic pressure from vomiting, coughing, or intense physical exertion. Its association with diabetic ketoacidosis (DKA) is extremely uncommon. We report a case of an 18-year-old male with poorly controlled type 1 diabetes who developed DKA complicated by pneumomediastinum, subcutaneous emphysema, and a small pneumothorax.

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  • Hamman syndrome is a rare, benign condition marked by air in the mediastinum without an external cause, usually affecting young adults and linked to activities that raise intrathoracic pressure, like coughing or asthma attacks.* -
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In 1939, Hamman´s syndrome, also know as spontaneous pneumomediastinum, was characterized by the presence of pneumothorax, subcutaneous emphysema, and pneumorrhachis. It is believed to arise from barotrauma during vaginal labor, causing alveolar membrane rupture and subsequent air leakage. Clinical manifestations are often nonspecific.

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  • - Hamman's syndrome is a rare complication of diabetic ketoacidosis (DKA) that causes subcutaneous emphysema and spontaneous pneumomediastinum, as demonstrated in a case involving an 11-year-old boy with newly diagnosed type 1 diabetes.
  • - The patient showed classic DKA symptoms like excessive thirst, frequent urination, abdominal pain, and fatigue and was initially treated with IV fluids and insulin before being transferred to a specialized children's hospital.
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Article Synopsis
  • A 70-year-old man with diabetes was treated with an SGLT2 inhibitor but developed vomiting and abdominal pain, leading to a diagnosis of diabetic ketoacidosis (DKA).
  • A CT scan revealed mediastinal emphysema, and treatment for DKA was initiated alongside concerns of potential Boerhaave syndrome.
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