Background And Aims: remains an important risk factor for noncardia gastric cancer and a spectrum of disease from infection to gastric cancer. As a step toward improved clinical strategies for gastric cancer prevention, we assessed racial differences in prevalence of from studies across the United States. This systematic review provides a comprehensive evaluation of the literature regarding racial differences in in the United States.
Methods: MEDLINE, Embase, and Web of Science database searches were performed through May 26, 2021. Ultimately, 25 studies that reported infection prevalence by race were included.
Results: All studies included in the review documented higher prevalence in Blacks and Hispanics than in whites. The ratio of prevalence for Blacks compared to non-Hispanic whites ranged from 1.3 to 5.4, and the ratio for Hispanics compared to non-Hispanic whites ranged from 1.8 to 4.4. Of the 5 studies that examined CagA prevalence by race, 4 found higher prevalence among Blacks and Hispanics compared to whites, with CagA prevalence ranging from 19% to 77% in whites, 62% to 90% in Blacks, and 64% to 74% in Hispanics.
Conclusion: In this review, across 25 studies, varying in underlying population, time period, and geographic location, Blacks and Hispanics appeared to have a higher prevalence of infection than whites. This increased prevalence of among populations also at a higher risk of gastric cancer is relevant in the clinical setting for decision-making related to testing and gastric cancer prevention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648414 | PMC |
| http://dx.doi.org/10.1016/j.gastha.2022.06.001 | DOI Listing |
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