AI Article Synopsis
- Research shows that while nicotine in drinking water doesn’t change disease severity in certain mice, prior exposure to nicotine reduces SARS-CoV-2 RNA and brain pathology.
- This suggests that nicotine's effects might be used to prevent neurological damage caused by the virus.
Article Abstract
Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645428 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-2183255/v1 | DOI Listing |
Publication Analysis
Top Keywords
likelihood sars-cov-2
8
sars-cov-2 rna
8
rna expression
8
nicotine
5
nicotine exposure
4
exposure decreases
4
decreases likelihood
4
sars-cov-2
4
expression neuropathology
4
neuropathology hace2
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!