Host genetic variability and determinants of severe COVID-19.

Trends Genet

Centre Antoine Lacassagne, Service de Valorisation Scientifique, F-06100 Nice, France. Electronic address:

Published: March 2023

Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak, convergent studies have provided evidence that host genetic background may contribute to the development of severe coronavirus disease (COVID-19). Here, we summarize how some genetic variations, such as in SARS-CoV-2 receptor angiotensin-converting enzyme 2 or interferon signaling pathway, may help to understand why some individuals can develop severe COVID-19.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9652763PMC
http://dx.doi.org/10.1016/j.tig.2022.10.003DOI Listing

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