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Clinical trials have shown favorable effects of exercise on frailty, supporting physical activity (PA) as a treatment and prevention strategy. Proteomics studies suggest that PA alters levels of many proteins, some of which may function as molecules in the biological processes underlying frailty. However, these studies have focused on structured exercise programs or cross-sectional PA-protein associations.
View Article and Find Full Text PDFAssociation Between Chewing Capacity and Mortality Risk: The Role of Diet and Ageing.
J Clin Periodontol
January 2025
Department of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Aim: Masticatory dysfunction due to tooth loss is a potentially modifiable risk for mortality, but the pathway behind that remains to be investigated. This prospective study aimed to examine the role of diet and ageing in the associations between chewing capacity and long-term mortality.
Methods: Data were obtained from participants (aged ≥ 20) in the National Health Nutritional and Health Survey (NHANES 1999-2010, n = 22,900).
Clinical Impact of Sarcopenia in the Decision-Making Process for Patients with Acute Diverticulitis.
J Clin Med
December 2024
UOC Chirurgia d'Urgenza e del Trauma, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Acute diverticulitis (AD), an inflammatory complication of diverticulosis, affects around 4% of individuals with diverticulosis, with increased incidence in older populations. This study aims to assess the impact of sarcopenia, the age-related loss of muscle mass, on the clinical decision-making and outcomes of patients with AD. A retrospective study was conducted on 237 patients admitted to the Emergency Department (ED) between January 2014 and February 2022.
View Article and Find Full Text PDFHIV and Inflamm-Aging: How Do We Reach the Summit of Healthy Aging?
Top Antivir Med
December 2024
University of Minnesota, Minneapolis, USA.
People with HIV (PWH) are living longer and experiencing a greater burden of morbidity from non-AIDS-defining conditions. Chronically treated HIV disease is associated with ongoing systemic inflammation that contributes to the development of chronic conditions (eg, cardiovascular disease) and geriatric syndromes (eg, frailty). Apart from HIV disease, a progressive increase in systemic inflammation is a characteristic feature of biologic aging, a process described as "inflammaging.
View Article and Find Full Text PDFMycophenolate Mofetil Induced-Colitis: Is it More about Clinical Diagnosis?
Curr Drug Saf
January 2025
Hull and East Yorkshire Hospitals NHS Trust, Department of Elderly/ Frailty Medicine, United Kingdom.
Background: Mycophenolate mofetil (MMF) is an immunosuppressant commonly used for treating autoimmune diseases.
Case Presentation: We report a diagnostically challenging case of MMF-induced colitis in a patient after 3 years of initiation of MMF therapy. A 76-year-old Caucasian female with a history of Chronic inflammatory demyelinating polyneuropathy receiving MMF presented to the hospital with a 7-weeks history of watery diarrhoea and crampy abdominal pains.
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