Background: Automated hematology analyzers deliver accurate and reliable hemoglobin measurement but they are expensive to afford for most of the developing countries like Ethiopia. Point of care hemoglobin analyzer like HemoCue301+ has potential to alleviate such problems. The main aim of this study was to compare the hemoglobin concentration measured by HemoCue301+ with the Sysmex KX-21N method at University of Gondar Com-prehensive Specialized Hospital, Gondar, Ethiopia, 2020.
Methods: A hospital based cross-sectional study with convenient sampling technique was employed from November to December 2020. Institutional ethics approval was obtained prior to sample utilization. A total of 147 specimens were analyzed by HemoCue301+ and Sysmex KX-21N hematology analyzer to compare the hemoglobin concentration measured by the two methods. Paired sample t-test and Bland-Altman plot were used to arrive at conclusions. SPSS version 20 and MedCalc software were used for analysis of the data.
Results: The paired sample t-test indicated the mean difference of the two measurements was 0.08299 with a standard deviation of 0.82332 and t-test: 1.222 at 146 degrees of freedom. There was no significant difference between the two measurements with a p-value of 0.224. The concordance correlation coefficient of the two methods was 0.956 (95% CI: 0.940 - 0.968, p < 0.0001). From the Bland-Altman plot, the limit of agreement was -1.50 - 1.70 g/dL with the mean difference of 0.08299 (95% CI: -0.05121 - 0.2172).
Conclusions: There was no significant difference in the hemoglobin measurement by the HemoCue and Sysmex KX-21N (coef = -0.127, 95% CI: -0.379 - 0.634). The HemoCue301+ may be used interchangeably with Sysmex-KX-21N automated hematology analyzers.
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