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Construction of Endometrial Carcinoma ceRNA Network and Screening of Key Genes Based on TCGA Database.
Comput Math Methods Med
July 2022
Department of Gynecology and Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Muping District, Yantai, Shandong 264100, China.
Objective: Long noncoding RNA (lncRNA) has received more and more attention in human tumor research. This study is aimed at clarifying the regulatory network of lncRNAs-microRNAs- (miRNAs-) mRNAs and at determining the relevant targets in the development of endometrial cancers.
Methods: Download the miRNA, mRNA, and lncRNA expression profile data of endometrial cancer patients from TCGA; use the "DESeq2" package of R software to identify the differential expression of miRNAs, mRNAs, and lncRNAs; construct a network of ceRNA; and perform gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment assessment on mRNAs in the network of ceRNA; string and Cytoscape 3.
Identification of Immune-Related Prognostic Markers in Gastric Cancer.
J Healthc Eng
May 2022
Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan 266042, Shandong, China.
Gastric cancer (GC) is a malignant tumor with a high fatality rate. Poor prognosis is the main cause of death caused by GC. In this study, the gene expression difference between GC and the control group was analyzed.
View Article and Find Full Text PDFLong noncoding RNA GAS5 inhibits metastasis by targeting miR-182/ANGPTL1 in hepatocellular carcinoma [Retraction].
Am J Cancer Res
October 2019
[This retracts the article on p. 108 in vol. 9, PMID: 30755815.
View Article and Find Full Text PDFLong noncoding RNA GAS5 inhibits metastasis by targeting miR-182/ANGPTL1 in hepatocellular carcinoma.
Am J Cancer Res
January 2019
Hepatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, Liaoning Province, China.
Intrahepatic and extrahepatic metastases are responsible for the majority of hepatocellular carcinoma (HCC)-related mortalities. Long noncoding RNAs (lncRNAs) exert important functions in modulating various tumor behaviors. However, the functions and mechanisms of lncRNAs in HCC metastasis remain largely unknown.
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