AI Article Synopsis
- - The study aims to compare the effectiveness of widefield optical coherence tomography angiography (WF-OCTA) and ultrawidefield fluorescein angiography (UWF-FA) in detecting retinal neovascularisation (NV) in patients with proliferative diabetic retinopathy (PDR).
- - Results show that WF-OCTA has a higher sensitivity (95%) for detecting PDR compared to ultrawidefield color fundus photography (78%), with strong agreement in certain quadrants but weaker in others.
- - The findings suggest that WF-OCTA could serve as a reliable, non-invasive alternative to traditional FA in diagnosing PDR, potentially enhancing clinical assessments.
Article Abstract
Aim: To assess the detection rate of retinal neovascularisation (NV) in eyes with proliferative diabetic retinopathy (PDR) using widefield optical coherence tomography angiography (WF-OCTA) in comparison to ultrawidefield fluorescein angiography (UWF-FA).
Methods: Single-capture 65°-WF-OCTA-imaging was performed in patients with NV at the disc or elsewhere (NVE) detected on UWF-FA using a modified PlexElite system and B-scans were examined for blood flow signals breaching the internal limiting membrane. Sensitivity of WF-OCTA and UWF colour fundus (UWF-CF) photography for correct diagnosis of PDR was determined and interdevice agreement (Fleiss' κ) between WF-OCTA and UWF-FA for detection of NV in the total gradable area and each retinal quadrant was evaluated.
Results: Fifty-nine eyes of 41 patients with PDR detected on UWF-FA were included. Sensitivity of detecting PDR on WF-OCTA scans was 0.95 in contrast to 0.78 on UWF-CF images. Agreement in detecting NVE between WF-OCTA and UWF-FA was high in the superotemporal (κ=0.98) and inferotemporal (κ=0.94) and weak in the superonasal (κ=0.24) and inferonasal quadrants (κ=0.42). On UWF-FA, 63% of NVEs (n=153) were located in the temporal quadrants with 93% (n=142) of them being detected on WF-OCTA scans.
Conclusion: The high reliability of non-invasive WF-OCTA imaging in detecting PDR can improve clinical examination with the potential to replace FA as a single diagnostic tool.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10804012 | PMC |
| http://dx.doi.org/10.1136/bjo-2022-322134 | DOI Listing |
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