AI Article Synopsis
- SLE is more common in African ancestry (AA) populations, with higher rates of leucopenia (low white blood cell count), particularly in those with the -CC genotype variant, prevalent in AA but rare in European ancestry (EA) populations.
- A study involving 764 SLE patients found that leucopenia rates were significantly higher in AA patients (60%) compared to EA patients (36.8%), with the -CC genotype linked to a higher prevalence of leucopenia in AA individuals.
- While AA patients also showed increased rates of thrombocytopenia and anemia, these conditions were not associated with the -CC genotype, suggesting potential implications for patient management in clinical settings.
Article Abstract
Objective: SLE is more prevalent in populations of African (AA) than European ancestry (EA) and leucopenia is common. A homozygous variant in (rs2814778-CC) is associated with lower white cell counts; the variant is common in AA but not EA populations. We hypothesised that in SLE: (1) leucopenia is more frequent in patients of AA than EA, and (2) the CC genotype accounts for the higher frequency of leucopenia in AA patients.
Methods: We performed a retrospective cohort study in patients with SLE at a tertiary care system. Ancestry was defined by genetic principal components. We compared the rate of leucopenia, thrombocytopenia and anaemia between (a) EA and AA patients, and (b) -CT/TT and CC genotype in AA patients.
Results: The cohort included 574 patients of EA and 190 of AA; -CC genotype was common in AA (70%) but not EA (0%) patients. Rates of leucopenia for ancestry and genotype were AA 60.0% vs EA 36.8 % (p=1.9E-08); CC 67.7% vs CT/TT 42.1% (p=9.8E-04). The rate of leucopenia did not differ by ancestry comparing EA patients versus AA with CT/TT genotype (p=0.59). Thrombocytopenia (22.2% vs 13.2%, p=0.004) and anaemia (88.4% vs 66.2%, p=3.7E-09) were more frequent in AA patients but were not associated with genotype (p=0.82 and p=0.84, respectively).
Conclusions: SLE of AA had higher rates of anaemia, leucopenia, and thrombocytopenia than those of EA; only the difference in leucopenia was explained by -CC genotype. This genotype could affect clinical practice.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664301 | PMC |
| http://dx.doi.org/10.1136/lupus-2022-000790 | DOI Listing |
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