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Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study. | LitMetric

Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study.

J Environ Sci (China)

NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100022, China.

Published: March 2023

AI Article Synopsis

  • The study investigated the impact of multiple endocrine disruptors (EDCs) on thyroid hormones in 177 healthy adults from China, measuring both serum thyroid hormone levels and urinary EDCs.
  • Results showed that, after accounting for various factors, bisphenol F (BPF) significantly correlated with lower levels of several thyroid hormones, while certain phthalate metabolites were positively linked to thyroid hormones.
  • The researchers highlighted a dose-response relationship between the mixture of EDCs and thyroid hormone levels, particularly emphasizing the strong influence of BPF on thyroid function, suggesting that even low-level EDC exposure could disrupt hormonal balance in healthy adults.

Article Abstract

Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and urinary levels of 11 EDCs, including six phthalate metabolites, bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), perchlorate, and thiocyanate among 177 healthy adults without occupational exposure. Associations of multiple urinary analytes with serum thyroid hormones were examined by performing general linear regression analysis and bayesian kernal machine regression analysis. These EDCs were detected in almost all samples. After adjusting for various covariates, we observed only BPF significantly associated with total thyroxin (TT4) (β=-0.27, 95% confidence interval (CI) [-0.41, -0.14]), total triiodothyronine (TT3) (β=-0.02 95% CI [-0.03, -0.01]), free T4 (fT4) (β=-0.02, 95% CI [-0.03, -0.01]), and free T3 (fT3) (β=-0.04, 95% CI [-0.07, -0.01]), and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and monoethyl phthalate (MEP) positively associated with TT4 (β=0.24, 95% CI [0.01, 0.48]) and fT4 (β=0.02, 95% CI [0.01, 0.04]), respectively. Moreover, we observed significant dose-response relationships between TT4 and the mixture of 11 EDCs, and BPF was the main contributor to the mixture effect, suggesting the priority of potential effect of BPF on disrupting thyroid function under a real scenario of human exposure to multiple EDCs. Our findings supported the hypothesis that human exposure to low levels of EDCs could alter thyroid hormones homeostasis among non-occupational healthy adults.

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Source
http://dx.doi.org/10.1016/j.jes.2022.01.017DOI Listing

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