Glioma is one of the most common intracranial malignant tumors worldwide, accounting for 30%-40% of primary brain tumors. Long non-coding RNAs (lncRNAs) have been implicated in cancer malignant progression. Glioma is classified into multiple subtypes, but lncRNA expression pattern in different subtypes are not fully described. Here, we reported that lncRNA-LINC00941 was highly expressed in all glioma subtypes. Overexpression of lncRNA-LINC00941 in U87 cells promoted cellular proliferation and invasiveness, and suppressed apoptosis. Our findings suggest that lncRNA-LINC00941 may function as an oncogenic factor in glioma, and targeting lncRNA-LINC00941 could be developed into a strategy for glioma management.
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| http://dx.doi.org/10.1016/j.neulet.2022.136964 | DOI Listing |
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Analysis of key lncRNA related to Parkinson's disease based on gene co-expression weight networks.
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From the School of Clinical Medicine (Liang, Luo, Jia), Shandong Second Medical University, Weifang, from the Department of Neurology (Liang, Zhao, Lin, Li, Luo, Jia) , Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University, Beijing, and from the Department of Neurology (Li), Affiliated Hospital of Weifang Medical University, Weifang, China.
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