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Epitranscriptomic turbo for autophagy boost: mA reader YTHDF3. | LitMetric
Mcroautophagy/autophagy plays an important role in maintaining homeostasis during nutrient starvation. However, whether epitranscriptomic events are involved in this process remains unclear. Our recent findings suggest that mA reader YTHDF3 has an essential role in autophagy induction. Elevated mA modifications installed by METTL3 enable YTHDF3 to promote autophagosome formation and lysosomal function upon nutrient deficiency. This is due to YTHDF3 binding to the mA modifications at the coding DNA sequence (CDS) and 3' untranslated region (UTR) around the stop codon of mRNA, recruiting EIF3A and EIF4B to facilitate FOXO3 translation, thus boosting autophagy. In this punctum, we discuss our finding for how YTHDF3 responds to nutrient starvation to promote autophagy flux, providing insights into RNA post-transcriptional modifications linking nutrient cues to autophagic upcycling.
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