AI Article Synopsis
- * Of the 26 cases studied, the majority were diagnosed at an early stage (Ann Arbor stage I), and staging did not correlate with prognosis, while treatment methods showed no significant effect on overall survival.
- * The 5- and 10-year survival rates are relatively high (83.1% and 78.2%), but being older than 70 years may pose a risk factor for worse survival, highlighting the need for standardized treatment protocols, with surgery being a potential primary option.
Article Abstract
Objectives: The present study explores an extremely rare disease, thymic mucosa-associated lymphoid tissue (MALT) lymphoma, for its characteristics and prognostic factors by analyzing the Surveillance, Epidemiology, and End Results (SEER) database.
Methods: From 2000 to 2018, cases with a diagnosed thymic MALT lymphoma were extracted. Clinical characteristics, treatments, and survival patterns of these cases were analyzed.
Results: Thymic MALT lymphoma (n = 26) accounted for 0.09% of all MALT lymphomas. With a sex ratio of 0.53 (male/female), 68% white population was affected. Most cases were diagnosed with Ann Arbor stage I (50%), yet advanced-stage did not show worse prognosis (p = 0.236). Different treatment protocols did not influence the overall prognosis (p > 0.99). The 5- and 10- year overall survival rates were 83.1% and 78.2%, respectively. Older than 70 years may be an independent risk factor for overall survival (HR = 7.166 [95% CI 1.173-43.756], p = 0.033).
Conclusion: Thymic MALT lymphoma is a highly rare disease with a favorable prognosis. Ann Arbor staging might not be appropriate to classify severity of this disease or its treatment. Older people may have worse survival. A standardized treatment mode needs to be established, and surgery could remain as the mainstay.
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| http://dx.doi.org/10.1080/14737140.2022.2146582 | DOI Listing |
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