AI Article Synopsis
- This review highlights the potential of 'mitoceuticals' as a neuroprotective approach for treating injuries to the nervous system by addressing mitochondrial dysfunction.
- It also mentions the successful transplantation of isolated exogenous mitochondria into the spinal cord, which boosts cellular energy and metabolism.
- Additionally, the use of erodible thermogelling hydrogels is discussed as a method to effectively deliver functioning mitochondria to damaged spinal tissue.
Article Abstract
Herein, we review evidence that targeting mitochondrial dysfunction with 'mitoceuticals' is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord parenchyma to increase overall cellular metabolism. We further discuss control measures to ensure greatest potential for mitochondrial transfer, notably using erodible thermogelling hydrogels to deliver respiratory competent mitochondria to the injured spinal cord.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9805511 | PMC |
| http://dx.doi.org/10.1016/j.mito.2022.11.001 | DOI Listing |
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