AI Article Synopsis
- A study evaluated the effectiveness of universal antigen rapid tests (ART) in preventing COVID-19 spread among hospitalized children aged 5 and older during the Omicron wave.
- Out of 444 hospitalized pediatric patients, ART showed a high accuracy with 93.7% agreement with PCR tests, and sensitivity of 83.3% and specificity of 97.5%.
- Findings suggested that while ART screening could help limit COVID-19 outbreaks in hospitals, its effectiveness is enhanced when combined with clinical symptoms and exposure assessment.
Article Abstract
Background: Clinical utility of universal antigen rapid test (ART) in the pediatric setting is unknown. We aimed to assess the performance and utility of universal ART in hospitalized children (≥5-year-old) to prevent nosocomial COVID-19 transmission.
Methods: Cross-sectional study involving all hospitalized pediatric patients aged ≥5-year-old from 2 periods during Omicron wave. Clinical data, ART and polymerase chain reaction test results were collected.
Results: A total of 444 patients were included from the 2 study periods, and 416 patients (93.7%) had concordant results between ART and polymerase chain reaction. The overall sensitivity and specificity of ART were 83.3% (95% CI: 75.2-89.3) and 97.5% (95% CI: 95.0-98.8), respectively. Negative predictive values of ART between the Omicron emergence and Omicron peak periods for a probable case group were 71.4% and 66.7%, respectively, and for a suspect case group 91.4% and 75.0%, respectively. Negative predictive values for an unlikely case group was >95% in both periods. Positive predictive value of ART was >85% for probable and suspect case groups in both periods. Seventy-five percent of patients (n = 15) who were incorrectly classified as SARS-CoV-2 negative by ART had potentially viable virus. No large nosocomial transmission clusters were detected.
Conclusions: Universal ART screening may limit nosocomial outbreaks in hospitalized children. The performance can be optimized by considering clinical symptoms, exposure and periods within COVID waves.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643321 | PMC |
| http://dx.doi.org/10.1016/j.ajic.2022.11.002 | DOI Listing |
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