Summary: The systems biology markup language (SBML) is an extensible standard format for exchanging biochemical models. One of the extensions for SBML is the SBML Layout and Render package. This allows modelers to describe a biochemical model as a pathway diagram. However, up to now, there has been little support to help users easily add and retrieve such information from SBML. In this application note, we describe a new Python package called SBMLDiagrams. This package allows a user to add a layout and render information or retrieve it using a straightforward Python API. The package uses skia-python to support the rendering of the diagrams, allowing export to commons formats such as PNG or PDF.
Availability And Implementation: SBMLDiagrams is publicly available and licensed under the liberal MIT open-source license. The package is available for all major platforms. The source code has been deposited at GitHub (github.com/sys-bio/SBMLDiagrams). Users can install the package using the standard pip installation mechanism: pip install SBMLDiagrams.
Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://dx.doi.org/10.1093/bioinformatics/btac730 | DOI Listing |
PLoS One
December 2024
School of Intelligent Manufacturing, Panzhihua University, Panzhihua, Sichuan, P. R. China.
Sensors (Basel)
November 2024
Department of Computer Science, University of Maryland, College Park, MD 20742, USA.
Temperature is an important control factor for biologics biomanufacturing in precision fermentation. Here, we explored a highly responsive low temperature-inducible genetic system (LowTempGAL) in the model yeast Saccharomyces cerevisiae. Two temperature biosensors, a heat-inducible degron and a heat-inducible protein aggregation domain, were used to regulate the GAL activator Gal4p, rendering the leaky LowTempGAL systems.
View Article and Find Full Text PDFSci Rep
April 2024
School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Optical field imaging technology does not require a complicated optical path layout and thus reduces hardware costs. Given that only one single exposure of a single camera can obtain three-dimensional information, this paper proposes an improved calibration method for depth measurement based on the theoretical model of optical field imaging. Specifically, the calibration time can be reduced since the Gaussian fitting can reduce the number of refocused images used to obtain the optimal refocusing coefficient calibration.
View Article and Find Full Text PDFHeliyon
March 2024
School of Public Policy and Urban Affairs, College of Social Sciences and Humanities, Northeastern University. 310 Renaissance Park, 1135 Tremont St, Boston, MA 02115, USA.
Green infrastructure is often proposed to complement conventional urban stormwater management systems that are stressed by extreme storms and expanding impervious surfaces. Established hydrological and hydraulic models inform stormwater engineering but are time- and data-intensive or aspatial, rendering them inadequate for rapid exploration of solutions. Simple spreadsheet models support quick site plan assessments but cannot adequately represent spatial interactions beyond a site.
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