An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was obtained through seven steps with 34.5% total yield, which is much higher than the process reported in the literature (11.0% total yield). The plausible ring-opening mechanism of 6,19-epoxy bridge in compound was first proposed and the structures of intermediates were supported by the LC-MS analysis of the reaction mixture.
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| http://dx.doi.org/10.1080/10286020.2022.2144260 | DOI Listing |
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