AI Article Synopsis
- Near-infrared laser therapy was tested in three major clinical trials for treating acute strokes, but the results did not support its efficacy.
- The review discusses the proposed mechanisms of how light stimulation could work in strokes, and examines various challenges in advancing this treatment, including issues with dosages and patient selection.
- The authors suggest that there may still be a future for transcranial light stimulation as a protective or restorative tool in stroke therapy.
Article Abstract
Near-infrared laser therapy, a special form of transcranial light therapy, has been tested as an acute stroke therapy in three large clinical trials. While the NEST trials failed to show the efficacy of light therapy in human stroke patients, there are many lingering questions and lessons that can be learned. In this review, we summarize the putative mechanism of light stimulation in the setting of stroke, highlight barriers, and challenges during the translational process, and evaluate light stimulation parameters, dosages and safety issues, choice of outcomes, effect size, and patient selection criteria. In the end, we propose potential future opportunities with transcranial light stimulation as a cerebroprotective or restorative tool for future stroke treatment.
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| http://dx.doi.org/10.1007/s12975-022-01103-7 | DOI Listing |
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