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"All-in-one" nano-system for smart delivery and imaging-guided combination therapy of triple-negative breast cancer.
J Colloid Interface Sci
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State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:
Triple-negative breast cancer (TNBC) with highly malignant and aggressive, still faces challenges in treatment due to the single treatment and side effects. It is urgent to develop an advanced theranostic platform against TNBC. Herein, an "all-in-one" nano-system Au/Cu nanodots/doxorubicin@nanospheres (Au/CuNDs/DOX@NS) with dual-responsive properties was designed for dual-mode imaging-guided combination treatment of TNBC.
View Article and Find Full Text PDFDually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin.
Acta Biomater
December 2024
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd. Richardson, TX 75080, United States; Department of Biomedical Engineering, The University of Texas at Dallas, 800 West Campbell Rd. Richardson, TX 75080, United States. Electronic address:
The skin, our largest organ, protects against environmental dangers but is vulnerable to various conditions like infections, eczema, dermatitis, psoriasis, skin cancer, and age-related collagen and elastin degradation. Its outer layer, the water-impermeable epidermis, presents challenges for passive drug delivery to the lower living layers of the skin. An ideal dermal delivery system should penetrate the epidermis and release treatments over time.
View Article and Find Full Text PDFTransition Metal Complex-Loaded Nanosystems: Advances in Stimuli-Responsive Cancer Therapies.
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December 2024
Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, 741246, India.
Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), as well as ultrasound-activated treatments like sonodynamic therapy (SDT). TMCNs based on ruthenium(II), rhenium(I), and iridium(III) improve PDT, while manganese(II) and iridium(III) demonstrate exceptional sonosensitizing properties.
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Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.
While glucose-responsive insulin delivery systems are in widespread clinical use to treat insulin insufficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains understudied. A self-regulated glucagon release material is highly desired to mitigate the potential risks of severe insulin-induced hypoglycemia. Here, we describe a glucose-responsive polymeric nanosystem with glucagon covalently grafted to the end-group.
View Article and Find Full Text PDFReactive oxygen species augmented polydopamine-chlorin e6 nanosystem for enhanced chemo/photothermal/photodynamic therapy: A synergistic trimodal combination approach in vitro & in vivo.
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Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, 278-8510, Chiba, Japan.
Article Synopsis
- The study explores a new cancer treatment approach that combines near-infrared laser phototherapies with chemotherapy, aiming to improve effectiveness while minimizing invasiveness and side effects.
- CuO nanoparticles were modified with a photosensitizer, chlorin e6, and coated with polydopamine to create a multifunctional drug delivery system that enhances targeted therapy.
- In vitro and in vivo experiments demonstrated that this nanoplatform, when used with laser irradiation, effectively increases cancer cell death and shows promise as a combined treatment strategy for better cancer management.
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