AI Article Synopsis
- PEDV is a coronavirus that causes severe diarrhea in newborn piglets and poses a major risk to the swine industry due to its high rates of illness and death.
- Currently available vaccines only work against older strains of the virus, leaving the newer, pandemic-causing strains without effective control measures.
- This review explores the biology of PEDV, including its transmission, structure, evolution, and interaction with hosts, aiming to identify factors that could improve prevention and treatment methods.
Article Abstract
The porcine epidemic diarrhea virus (PEDV) is a member of the coronavirus family, causing deadly watery diarrhea in newborn piglets. The global pandemic of PEDV, with significant morbidity and mortality, poses a huge threat to the swine industry. The currently developed vaccines and drugs are only effective against the classic GI strains that were prevalent before 2010, while there is no effective control against the GII variant strains that are currently a global pandemic. In this review, we summarize the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus-host interaction, in an attempt to find the potential virulence factors influencing PEDV pathogenesis. We conclude with the mechanism by which PEDV components antagonize the immune responses of the virus, and the role of host factors in virus infection. Essentially, this review serves as a valuable reference for the development of attenuated virus vaccines and the potential of host factors as antiviral targets for the prevention and control of PEDV infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695474 | PMC |
| http://dx.doi.org/10.3390/v14112434 | DOI Listing |
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