is associated with substantial economic losses in the fish industry and with food-borne illness in humans. This study aimed to determine the prevalence, antibiogram profiles, sequence analysis, virulence and antimicrobial resistance genes, and pathogenicity of recovered from . A total of 80 fish were randomly gathered from various private farms in Suez Province, Egypt. Subsequently, samples were subjected to clinical, post-mortem, and bacteriological examinations. The retrieved isolates were tested for sequence analysis, antibiogram profile, pathogenicity, and PCR detection of virulence and resistance genes. The prevalence of in the examined was 22.5 % (18/80). The phylogenetic analyses revealed that the tested strains shared high genetic similarity with other strains from India, UK, and China. Using PCR it was revealed that the retrieved isolates harbored the A, , , AII, , , and virulence genes with prevalence of 100%, 82.9%, 61.7%, 55.3%, 44.7%, 36.17%, and 29.8%, respectively. Our findings revealed that 29.8% (14/47) of the retrieved strains were XDR to nine antimicrobial classes and carried , , A, A1, and 1 resistance genes. Likewise, 19.1% (9/47) of the obtained strains were MDR to eight classes and possessed , , A, A1, and 1 genes. The pathogenicity testing indicated that the mortality rates positively correlated with the prevalence of virulence-determinant genes. To our knowledge, this is the first report to reveal the occurrence of XDR and MDR in , an emergence that represents a risk to public health. Emerging XDR and MDR in frequently harbored A, , , AII, and virulence genes, and , 1, A, , , and A1 resistance genes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695981PMC
http://dx.doi.org/10.3390/pathogens11111262DOI Listing

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