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Effects of Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. | LitMetric

AI Article Synopsis

  • The study examined the impact of Irvingia gabonensis (IG) extract on various health metrics in overweight/obese individuals over a 12-week period.
  • Participants were split into two groups, one receiving IG and the other a placebo, with measurements taken at multiple points throughout the study.
  • Results showed that IG led to increases in plasma vitamin C and adiponectin levels, suggesting potential benefits in reducing obesity-related health issues, although no significant differences were found in metabolism, inflammation, or aerobic capacity between the groups.

Article Abstract

We investigated the effects of Irvingia gabonensis (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (p < 0.01) and 12 weeks (p < 0.05) and serum adiponectin after 3 weeks (p < 0.05). Compared with before supplementation, plasma malondialdehyde in the IG and serum leptin in the PLA were decreased after 12-week supplementation, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656030PMC
http://dx.doi.org/10.3390/nu14214646DOI Listing

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