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The Isolation, Structure Elucidation and Bioactivity Study of Chilensosides A, A, B, C, and D, Holostane Triterpene Di-, Tri- and Tetrasulfated Pentaosides from the Sea Cucumber (Caudinidae, Molpadida). | LitMetric

AI Article Synopsis

Article Abstract

Five new triterpene (4,4,14-trimethylsterol) di-, tri- and tetrasulfated pentaosides, chilensosides A (), A (), B (), C (), and D () were isolated from the Far-Eastern sea cucumber . The structures were established on the basis of extensive analysis of 1D and 2D NMR spectra and confirmed by HR-ESI-MS data. The structural variability of the glycosides concerned the pentasaccharide chains. Their architecture was characterized by the upper semi-chain consisting of three sugar units and the bottom semi-chain of two sugars. Carbohydrate chains of compounds - differed in the quantity and positions of sulfate groups. The interesting structural features of the glycosides were: the presence of two sulfate groups at C-4 and C-6 of the same glucose residue in the upper semi-chain of , , , and and the sulfation at C-3 of terminal glucose residue in the bottom semi-chain of that makes its further elongation impossible. Chilensoside D () was the sixth tetrasulfated glycoside found in sea cucumbers. The architecture of the sugar chains of chilensosides A-D (-), the positions of sulfation, the quantity of sulfate groups, as well as the aglycone structures, demonstrate their similarity to the glycosides of the representatives of the order Dendrochirotida, confirming the phylogenetic closeness of the orders Molpadida and Dendrochirotida. The cytotoxic activities of the compounds - against human erythrocytes and some cancer cell lines are presented. Disulfated chilensosides A () and B () and trisulfated chilensoside C () showed significant cytotoxic activity against human cancer cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658831PMC
http://dx.doi.org/10.3390/molecules27217655DOI Listing

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