AI Article Synopsis
- * G-6 was found to inhibit colony formation and cell movement, and it induced apoptosis in SW1990 pancreatic cancer cells, focusing on the differential expression of 143 proteins.
- * The study identified the MET/PTEN/TGF-β signaling pathway as a key regulator of important biological processes, which may suggest G-6's role as a promising treatment for pancreatic cancer.
Article Abstract
Natural products (NPs) were a rich source of diverse bioactive molecules. Most anti-tumor agents were built on natural scaffolds. DC. was an important plant used to process the traditional Chinese herbal medicines "gansong". Pancreatic cancer was the fourth most common cause of cancer-related death in the world. Hence, there was an urgent need to develop novel agents for the treatment of pancreatic cancer. In this paper, nardoguaianone L (G-6) is isolated from , which inhibited SW1990 cells colony formation and cell migration, and induced cell apoptosis. Furthermore, we analyzed the differential expression proteins after treatment with G-6 in SW1990 cells by using iTRAQ/TMT-based quantitative proteomics technology, and the results showed that G-6 regulated 143 proteins' differential expression by GO annotation, including biological process, cellular component, and molecular function. Meanwhile, KEGG enrichment found that with Human T-cell leukemia virus, one infection was the most highly enhanced pathway. Furthermore, the MET/PTEN/TGF-β pathway was identified as a significant pathway that had important biological functions, including cell migration and motility by PPI network analysis in SW1990 cells. Taken together, our study found that G-6 is a potential anti-pancreatic cancer agent with regulation of MET/PTEN/TGF-β pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656649 | PMC |
| http://dx.doi.org/10.3390/molecules27217490 | DOI Listing |
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