AI Article Synopsis
- Natural products have diverse structures that contribute to their effectiveness against various diseases, including cancers, with almost 65% of anticancer drugs being derived from them.
- Advances in biosynthetic technologies are leading to the discovery and development of more natural products as potential candidates for cancer therapy.
- The text summarizes anticancer natural products approved between 1950 and 2021, discusses their mechanisms of action, and reviews synthetic biology tools used in their development.
Article Abstract
Natural products have multifarious bioactivities against bacteria, fungi, viruses, cancers and other diseases due to their diverse structures. Nearly 65% of anticancer drugs are natural products or their derivatives. Thus, natural products play significant roles in clinical cancer therapy. With the development of biosynthetic technologies, an increasing number of natural products have been discovered and developed as candidates for clinical cancer therapy. Here, we aim to summarize the anticancer natural products approved from 1950 to 2021 and discuss their molecular mechanisms. We also describe the available synthetic biology tools and highlight their applications in the development of natural products.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656990 | PMC |
| http://dx.doi.org/10.3390/molecules27217480 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!