Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye.

Int J Mol Sci

Section of Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy.

Published: November 2022

Vision is one of the dominant senses in humans and eye health is essential to ensure a good quality of life. Therefore, there is an urgent necessity to identify effective therapeutic candidates to reverse the progression of different ocular pathologies. Activity-dependent neuroprotective protein (ADNP) is a protein involved in the physio-pathological processes of the eye. Noteworthy, is the small peptide derived from ADNP, known as NAP, which shows protective, antioxidant, and anti-apoptotic properties. Herein, we review the current state of knowledge concerning the role of ADNP in ocular pathologies, while providing an overview of eye anatomy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9658893PMC
http://dx.doi.org/10.3390/ijms232113654DOI Listing

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