Genotypes Modulate Inflammation Independently of Their Effect on Lipid Metabolism.

The association between genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS. genotyping was carried out by the Sanger method in both cohorts. carriers had significantly lower levels of CRP than carriers. Furthermore, 4 carriers had cholesterol-enriched LDL particles compared to carriers. carriers also had higher concentrations of small, medium, and large LDL particles. CRP levels were not associated with lipoprotein particle number, size, or composition. GlycA levels were not associated with genotypes. However, GlycA levels were significantly associated with the size and the amount of cholesterol contained in HDL, VLDL, and LDL particles. genotype influences CRP concentration regardless of lipid profile. carriers showed the highest CRP levels, followed by and . A more atherogenic lipid profile, but not inflammatory markers could partly explain the higher CVD risk observed in carriers.